教授、博士生导师 、“弘深优秀学者”
学习经历
2002.09-2005.06，中国人民解放军第三军医大学，劳动卫生与环境卫生学，博士
1999.09-2002.06，中国人民解放军第三军医大学，劳动卫生与环境卫生学，硕士
1993.09-1998.07，中国人民解放军第三军医大学，检验医学，学士
工作经历
2022.05-至今，开云平台(中国)有限公司，教授、博导
2017.11-2022.05，浙江大学医开云平台(中国)有限公司环境医学系主任、“百人计划”特聘研究员、博导
2012.09-2017.11，中国人民解放军第三军医大学预防系劳动卫生学教研室，教授、博导
2009.09-2012.09，中国人民解放军第三军医大学预防系劳动卫生学教研室，副教授、硕导
2012.03-2012.06，法国波尔多第一大学IMS实验室，教育部公派高级访问学者
2006.12-2009.02，美国密西根州立大学公卫开云平台(中国)有限公司，博士后
2005.08-2009.08，中国人民解放军第三军医大学预防系劳动卫生学教研室，讲师
学术任职
中国毒理学会（国家一级学会） 理事
中国环境诱变剂学会生物标志物专业委员会 副主任委员/常委
中国环境诱变剂学会生物标志物专业委员会 副主任委员/常委
中国生物医学工程学会生物电磁专业委员会 候任主任委员/副主任委员
研究方向、教学课程
研究方向：
1. 环境与职业有害因素健康危害效应、与疾病的关联和毒理效应机制以及防护新策略
2. 环境与职业有害因素暴露与神经退行性疾病关联机制与防治
教学课程：劳动卫生学、环境卫生学、卫生毒理、
成果（1.文章2.专利3.项目4.获奖）：
近五年发表的部分论文（*通讯作者#第一作者）：
1. Yang Yue, Miduo Tan, Yan Luo, Ping Deng, Hui Wang, Jingdian Li, Rongrong Hao, Li Tian, Jia Xie, Mengyan Chen, Zhengping Yu, Zhou Zhou*, Huifeng Pi*. miR-36145-p downregulation promotes cadmium-induced breast cancer cell proliferation and metastasis by targeting TXNRD1. Ecotoxicology and Environmental Safety. 2022, 247: DOI: 10.1016/j.ecoenv.2022.114270
2. Ping Deng, Huadong Zhang, Liting Wang, Sheng Jie, Qi Zhao, Fengqiong Chen, Yang Yue, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Zhengping Yu, Huifeng Pi*, Zhou Zhou*. Long-term cadmium exposure impairs cognitive function by activating lnc-Gm10532/m6A/FIS1 axis-mediated mitochondrial fission and dysfunction. Science of the Total Environment. 2022, 858: DOI: 10.1016/j.scitotenv.2022.159950
3. Zhixin He, Yajing Zhang, Huijie Zhang, Chao Zhou, Qinlong Ma, Ping Deng, Muxue Lu, Zhenlin Mou, Min Lin, Lingling Yang, Yanqi Li, Yang Yue, Huifeng Pi, Yonghui Lu, Mindi He, Lei Zhang, Chunhai Chen,* Zhou Zhou*, Zhengping Yu*. NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by inhibiting oxidative stress in Oli-neu cells. Ecotoxicology and Environmental Safety. 2022, 223: DOI: 10.1016/j.ecoenv.2021.112554
4. Tong, T, Duan, WX, Xu, YD , Hong, HH, Xu, J, Fu, GY, Wang, X, Yang, LL, Deng, P, Zhang, JJ, He, HT, Mao, GF, Lu, YQ, Lin, XQ, Yu, ZP, Pi, HF, Cheng, Y*, Xu, S*C, Zhou Zhou*. Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain. Environment International. 2022, 169: DOI: 10.1016/j.envint.2022.107512
5. Huihui Hong, Xiqin Lin, Yudong Xu, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Yuanqiang Lu*, Zhou Zhou*. Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells. Science of the Total Environment. 2022, 849: DOI: 10.1016/j.scitotenv.2022.157819
6. Zhixin He, Yudong Xu, Qinlong Ma, Chao Zhou, Lingling Yang, Min Lin, Ping Deng, Zhiqi Yang, Mingyue Gong, Huijie Zhang, Muxue Lu, Yanqi Li, Peng Gao, Yonghui Lu, Mindi He, Lei Zhang, Huifeng Pi, Kuan Zhang, Song Qin, Zhengping Yu*, Zhou Zhou*, Chunhai Chen*. SOX2 modulated astrocytic process plasticity is involved in arsenic-induced metabolic disorders. Journal of Hazardous Materials. 2022, 435: DOI: 10.1016/j.jhazmat.2022.128942
7. Tengfei Fan, Xiaoning Wang, Sheng Zhang, Ping Deng, Yi Jiang, Yidan Liang, Sheng Jie, Qing Wang, Chuwen Li, Guocai Tian, Zhen Zhang, Zhenhu Ren, Bo Li, Yanrong Chen, Zhijing He, Yan Luo, Mingliang Chen, Hanjiang Wu, Zhengping Yu, Huifeng Pi*, Zhou Zhou* and Zhiyuan Zhang*. NUPR1 promotes the proliferation and metastasis of oral squamous squamous cell carcinoma cells by activating TFE3-dependent autophagy. Signal Transduction and Targeted Therapy. 2022, 7(1): DOI: 10.1038/s41392-022-00939-7
8. Yang Yue, Ping Deng, Heng Xiao, Miduo Tan, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Liting Wang, Yidan Liang, Huifeng Pi*, Zhou Zhou*, Zhengping Yu*. N6-methyladenosine-mediated downregulation of miR-374c-5p promotes cadmium-induced cell proliferation and metastasis by targeting GRM3 in breast cancer cells. Ecotoxicology and Environmental Safety. 2022, 229: DOI: 10.1016/j.ecoenv.2021.113085
9. Huihui Hong, Haotian He, Xiqin Lin, Tali Hayuehashi, Jia Xu, Jingjing Zhang, Yudong Xu, Tong Tong, Yuanqiang Lu*, Zhou Zhou*. Cadmium exposure suppresses insulin secretion through mtROS-mediated mitochondrial dysfunction and inflammatory response in pancreatic beta cells. Journal of Trace Elements in Medicine and Biology. 2022, 71: DOI: 10.1016/j.jtemb.2022.126952
10. Huihui Hong, Jia Xu, Haotian He,Xue Wang, Lingling Yang, Ping Deng, Lu Yang, Miduo Tan, Jingjing Zhang, Yudong Xug, Tong Tong, Xiqin Lin, Huifeng Pi,* Yuanqiang Lu*, Zhou Zhou*. Cadmium perturbed metabolomic signature in pancreatic beta cells correlates with disturbed metabolite profile in human urine. Environment International. 2022, 161: DOI: 10.1016/j.envint.2022.107139
11. Yidan Liang, Huifeng Pi, Lingzhi Liao, Miduo Tan, Ping Deng, Yang Yue, Yu Xi , Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Mingliang Chen, Liting Wang, Zhengping Yu, Zhou Zhou*. Cadmium promotes breast cancer cell proliferation, migration and invasion by inhibiting ACSS2/ATG5-mediated autophagy. Environmental Pollution. 2021, 273: DOI: 10.1016/j.envpol.2021.116504
12. Yidan Liang, Lai Yi, Ping Deng, Liting Wang, Yang Yue, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Zhengping Yu, Huifeng Pi*, Zhou Zhou*. Rapamycin antagonizes cadmium-induced breast cancer cell proliferation and metastasis through directly modulating ACSS2. Ecotoxicology and Environmental Safety. 2021, 224: DOI: 10.1016/j.ecoenv.2021.112626
13. Ping Deng, Miduo Tan, Wei Zhou, Chunhai Chen, Yu Xi, Peng Gao, Qinlong Ma, Yidan Liang, Mengyan Chen, Li Tian, Jia Xie, Mengyu Liu, Yan Luo, Yanqi Li, Lei Zhang, Liting Wang, Youlong Zeng, Huifeng Pi*, Zhengping Yu*, Zhou Zhou*. Bisphenol A promotes breast cancer cell proliferation by driving miR-381-3p-PTTG1-dependent cell cycle progression. Chemosphere. 2021, 268: DOI: 10.1016/j.chemosphere.2020.129221
14. Chao Zhou, Mengyu Liu, Xiang Mei, Qian Li, Wenjuan Zhang, Pingeng, Zhixin He, Yu Xi, Tong Tong, Huifeng Pi, Yonghui Lu,hunhaihen, Lei Zhang, Zhengping Yu*, Zhou Zhou*, Mindi He*. Histone hypoacetylation contributes to neurotoxicity induced by chronic nickel exposure in vivo and in vitro. Science of the Total Environment. 2021, 783: DOI: 10.1016/j.scitotenv.2021.147014
15. Huihui Hong, Yudong Xu, Jia Xu, Jingjing Zhang, Yu Xi, Huifeng Pi, Lingling Yang, Zhengping Yu, Qingqian Wu, Zhuoxian Meng, Shuzhen Xu, Yunzhao Ren, Wei-shuyi Ruan, Yuan-qiang Lu*, Zhou Zhou*. Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism. Environment International. 2021, 149: DOI: 10.1016/j.envint.2021.106406
16. Mengyu Liu, Huifeng Pi, Yu Xi, Liting Wang, Li Tian, Mengyan Chen, Jia Xie, Ping Deng, Tao Zhang, Chao Zhou, Yidan Liang, Lei Zhang, Mindi He, Yonghui Lu, Chunhai Chen, Zhengping Yu* and Zhou Zhou*. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy. 2021, 17(4): 903-924
17. Qinlong Ma，Ping Deng，Min Lin, Lingling Yang , Le Li, Lu Guo, Lei Zhang, Mindi He, Yonghui Lu, Huifeng Pi, Yanwen Zhang, Zhengping Yu, Chunhai Chen* and Zhou Zhou*. Long-term bisphenol A exposure exacerbates diet-induced prediabetes via TLR4-dependent hypothalamic inflammation. Journal of Hazardous Materials. 2021, 402: DOI: 10.1016/j.hazmat.2020.123926
18. Ping Deng, Qinlong Ma, Yu Xi, Lingling Yang, Min Lin, Zhengping Yu, Chunhai Chen* and Zhou Zhou*. Transcriptomic insight into cadmium-induced neurotoxicity in embryonic neural stem/progenitor cells. Toxicology in Vitro. 2020, 62: DOI: 10.1016/j.tiv.2019.104686
19. Mindi He, Chao Zhou, Yonghui Lu, Ling Mao, Yu Xi, Xiang Mei, Xue Wang, Lei Zhang, Zhengping Yu and Zhou Zhou*. Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210 /ISCU Axis Activation. Oxidative Medicine and Cellular Longevity. 2020, 2020: DOI:10.1155/2020/5406284
20. Li Pang, Ping Deng, Yi-Dan Liang, Jing-Yu Qian, Li-Chuan Wu, Ling-Ling Yang, Zheng-Ping Yu, Zhou Zhou*. Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress. Toxicology Research. 2019, 8(6): 918-927
21. Huifeng P, Mengyu Liu, Yu Xi ,Mengyan Chen, Li Tian, Jia Xie, Mingliang Chen, Zhen Wang, Min Yang, Zhengping Yu, Zhou Zhou* and Feng Gao*. Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery. FASEB Journal. 2019, 33(11): 11870-11883
22. Yu Xi, Mengyu Liu, Shuzhen Xu, Huihui Hong, Mengyan Chen, Li Tian, Jia Xie, Ping Deng, Chao Zhou, Lei Zhang, Mindi He, Chunhai Chen, Yonghui Lu, Russel J. Reiter, Zhengping Yu, Huifeng Pi, Zhou Zhou*. Inhibition of SERPINA3N-dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride-induced neurotoxicity. Journal of Pineal Research. 2019, 67(3): DOI: 10.1111/jpi.12596
23. Pi H, Li M, Zou L, Yang M, Deng P, Fan T, Liu M, Tian L, Tu M, Xie J, Chen M, Li H, Xi Y, Zhang L, He M, Lu Y, Chen C1, Zhang T, Wang Z, Yu Z, Gao F, Zhou Zhou*. AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells. Autophagy. 2019, 15(4): 565-582
24. Pi H, Wang Z, Liu M, Deng P, Yu Z, Zhou Zhou* and Gao F*. SCD1 activation impedes foam cell formation by inducing lipophagy in oxLDL-treated human vascular smooth muscle cells. Journal of Cellular and Molecular Medicine. 2019, 23(8): 5259-5269
25. Pi H, Li M, Xie J, Yang Z, Xi Y, Yu Z* and Zhou Zhou*. Transcription factor E3 protects against cadmium-induced apoptosis by maintaining the lysosomal-mitochondrial axis but not autophagic flux in Neuro-2a cells. Toxicology Letters. 2018, 295: 335-350
26. Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He,Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J. Reiter, Zhengping Yu*, Hanjiang Wu*, Zhou Zhou*. Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma. Journal of Pineal Research. 2018, 64(2): DOI: 10.1111/jpi.12457
27. Chunhai Chen*, Qinglong Ma, Ping Deng, Jianjing Yang, Lingling Yang, Min Lin, Zhengping Yu, Zhou Zhou*. Critical role of TRPC1 in thyroid hormone-dependent dopaminergic neuron development. Biochimica et Biophysica Acta-Molecular Cell Research. 2017, 1864(10): 1900-1912
28. Qian Li, Min-Di He, Lin Mao, Xue Wang, Yu-Lin Jiang, Min Li, Yong-Hui Lu, ZhengPing Yu* and Zhou Zhou*. Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells. Cellular Physiology and Biochemistry. 2017, 41(5): 2016-2026
29. Huifeng Pi, Min Li, Li Tian1, Zhiqi Yang, Zhengping Yu, Zhou Zhou*. Enhancing lysosomal biogenesis and autophagic fux by activating the transcription factor EB protects against cadmium-induced neurotoxicity. Scientific Reports. 2017, 7: DOI: 10.1038/srep43466
30. Xiaojie Cao, Lili Zhang, Chunhai Chen, Qingsong Wang, Lu Guo, Qinlong Ma, Ping Deng, Gang Zhu, Binghu Li, Yan Pi, Chunyan Long, Lei Zhang, Zhengping Yu, Zhou Zhou* and Jingcheng Li*. The critical role of ABCG1 and PPARγ/LXRα signaling in TLR4 mediates inflammatory responses and lipid accumulation in vascular smooth muscle cells. Cell and Tissue Research. 2017, 368(1): 145-157
31. Zhengwang Cao, Yiliang Fang, Yonghui Lu, Dunxian Tan, Changhong Du, Yuming Li, Qinlong Ma, Junmei Yu, Mengyan Chen, Chao Zhou, Liping Pei, Lei Zhang, Haiying Ran, Mindi He, Zhengping Yu* and Zhou Zhou*. Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome. Journal of Pineal Research. 2017, 62(3): DOI: 10.1111/jpi.12389
科研项目
1. 国家级基金项目：
主持国家自然科学基金优秀青年基金项目1项、面上项目2项；主持国家重点基础研究计划“973计划”子课题1项；
2. 省或市级基金项目：
主持重庆市杰出青年基金1项，主持中国人民解放军“十三五”后勤科研重大项目1项。
获奖
2017年 中国人民解放军军队科技进步二等奖1项（第二完成人）
